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Paradoxis
Starting Member
8 Posts |
 Posted - 07/04/2006 : 04:41:52
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I've been on Zoloft (200 mg/day) for major depression for several years now, and for me it's been a miracle drug. However, in the last few months it has unaccountably stopped working and the depression has returned. It's devastating. I've continued to take it as usual, so I'm wondering what would cause it to become ineffective after all this time?
Can the onset of perimenopause change how the drug works? Has any research been done on this? I'm wondering if my current depression is hormonally induced, then what can I do and should I still be taking Zoloft or something else?
Any comments or suggestions would be very much appreciated, as I don't know if I can continue this way indefinitely.
Sincerely,
Para.
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| RNT
Starting Member
1 Posts |
Posted - 08/02/2006 : 20:54:35
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| THAT SOUNDS LIKE WHAT I WAS THINKING, THAT MY MEDICATION MIGHT NOT BE WORKING BECAUSE OF SOMETHING ELSE THAT MIGHT BE GOING ON INSIDE MY BODY, HORMONAL PREMENOPAUSE OR I'M EVEN THINKING MY THYROID HAS BEEN MESSING ME UP FOR YEARS. THERE ARE SO MANY MEDICATIONS THAT DON'T HAVE ANY EFFECT ON ME AT ALL. I'M THINKING BECAUSE I HAVE SO MANY THINGS WRONG WITH ME, ITS A VICIUOS CIRCLE. THIS FOR THAT BUT DOES SOMETHING ELSE TO THE OTHER THING AND VISA VERSA. MAKES YOU FEEL LIKE A GINNYPIG FOR DOCTORS. THEY CAN'T FIGURE OUT ALL MY PROBLEMS EFFECTS AND REACTIONS. ITS TRY IT AS YOU GO. THATS LIFE SOME GOOD DAYS SOME BAD. I'M NOT SURE HOW THIS PROGRAM WORKS. I HAVE NO IDEA WHAT I'M DOING???????????? |
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| Megpie71
Starting Member
9 Posts
Gratitude: 8
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Posted - 04/21/2007 : 07:53:48
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I recently had my dosage of Zoloft altered, because the previous dose (100mg/day) had just stopped working. It stopped very gradually over the course of a year, and I didn't even suspect it until I started getting the miseries on a regular basis. At that point, I figured it was hormonal (I usually have a bit of a miserable time just before my period, when the PMS overwhelms the Zoloft). What made me realise it was more than that was seeing that my creativity had been pretty much on hold for over a year, *and* that I was feeling miserable just after my period as well.
I'm on Thyroxine as well, and I was getting the dosage of that altered, too, because I was showing up as being just a little bit under-medicated. According to my GP, Zoloft and thyroxine have a slight countering effect on each other, so if you're on one of them, you may need to increase your dosage of the other (or vice versa) in order to get the full effect.
As always, check with your GP and your Pdoc - and give them a full list of *everything* you're taking, including herbal products, vitamin tablets, mineral supplements and similar, as well as tea, coffee, cigarettes, alcohol, and cola drinks. It may just be that things are a little out of whack metabolically (and perimenopause is one of those times where the hormone levels can play merry hells with things), but either way, let them know what other things you're putting into your system, so they can see if there's any chance that the gestalt effect of two or three things might be dampening things down.
Real Daleks don't climb stairs. They level the building.
- Science Fiction convention joke.
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Zoloft stops working after time?
