Had success for a very short while with Manerix (Moclobemide) but after increase in dosage it poops out in only a week or so. Longest it lasted was at 600mg for about 3-4 weeks. .. I'm up to 900mg now (max the dr. said) and only felt better for about a week and I'm very down now. Hard to get out of bed; I'm just sooooo tired. Totally bummed... Want to do nothing all day... been 2 weeks since I cleaned the bathrooms... a struggle just to make dinner for the family.. .. Hard to find info as it's not a popular med. .. Other meds tried are Effexor (not effective and just had uncomfortable brain "swooshes") .. Then tried Celexa but could not orgasm. (also uncomfortable)... Posted this a few weeks ago in the Moclobemide section with no reply and thought maybe this section might get more people reading it. I do have an appt with the dr but not for 2 weeks.. So thought I'd post here to see if anyone else had trouble with Moclobemide poop-out. .. What should I try next.. I don't want any sexual side effects... Thanks.. Tracy